Chloramphenicol loaded polylactide melt electrospun scaffolds for biomedical applications
نویسندگان
چکیده
Melt electrospinning of polylactide (PLA) loaded with chloramphenicol (CAM) has been performed and characteristics fibers, physical properties scaffolds, CAM release behavior, antibacterial biocompatibility have evaluated. The interest samples is nowadays enhanced for biomedical applications since this antibiotic demonstrated to be efficient the treatment cancer. selected as an ideal preparation process because it avoids use toxic solvents which are harmful environment could problematic applications. rendered fibers a relatively large diameter (between 20 μm 40 depending on load) minimum polymer degradation. Characteristics melt electrospun scaffolds were also compared those prepared by solution electrospinning. Differences consisted in more sustained higher processed samples. Bactericide effect was evaluated evidence maintenance bioactivity after processing at high temperature slower caused constitutive fibers. Since pure showed thermal degradation temperatures close PLA melting temperature, complete analysis well performed. Invariant Kinetic Parameters method allowed determining initial decomposition step that followed autoaccelatory Avrami model, then autocatalytic reaction took place conversions than 50%. Dispersion matrix enhances stability antibiotic, onset 16 °C melt-electrospun liquid state CAM.
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2021
ISSN: ['0378-5173', '1873-3476']
DOI: https://doi.org/10.1016/j.ijpharm.2021.120897